A chemical byproduct, or metabolite, created as the body breaks down ketamine likely holds the secret to its rapid antidepressant action, National Institutes of Health (NIH) scientists and grantees have discovered. This metabolite singularly reversed depression-like behaviors in mice without triggering any of the anesthetic, dissociative, or addictive side effects associated with ketamine.
“This discovery fundamentally changes our understanding of how this rapid antidepressant mechanism works and holds promise for the development of more robust and safer treatments,” said Carlos Zarate, M.D. of the NIH’s National Institute of Mental Health (NIMH), a study co-author and a pioneer of research using ketamine to treat depression. “By using a team approach, researchers were able to reverse-engineer ketamine’s workings from the clinic to the lab to pinpoint what makes it so unique.
Clinical trials by Zarate and others have shown that Ketamine liquid supplier can lift depression in hours, or even minutes – much faster than the most commonly used antidepressant medications now available, which often require weeks to take effect. Further, the antidepressant effects of a single dose can last for a week or longer.
IV Ketamine Studied By Doctors At Yale
Doctors at Yale University discovered that in tiny doses, FDA Approved Ketamine that is delivered via IV infusion, has been effective in relieving treatment-resistant depression (TRD), Anxiety, OCD, PTSD, Phantom Pain, Trigeminal Neuralgia, RSD, Fibromyalgia, Migraines, and Neuropathy.
If you haven’t had success in finding relief — IV Ketamine Therapy may be right for you.
Experts from The National Institute of Mental Health have said, “IV Ketamine Therapy may be the most important treatment breakthrough in decades”.
Ketamine Recognized As An Emerging Treatment For CRPS
Investigators are using low doses of Ketamine—a strong anesthetic—given intravenously for several days to either reduce substantially or eliminate the chronic pain of Complex Regional Pain Syndrome (CRPS). In certain clinical settings, Ketamine has been shown to be useful in treating pain that does not respond well to other treatments.
Medical Articles & Studies on IV Ketamine Infusion
Below you’ll find links to medical articles and studies related to Ketamine therapy. We will continue to update this helpful list.
Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
Ketamine as a novel antidepressant: from synapse to behavior
Serial infusions of low-dose ketamine for major depression (abstract)
Neurobiological advances identify novel antidepressant targets
The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases
Synaptic Dysfunction in Depression-Potential Therapeutic Targets Ketamine
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
Efficacy of Intravenous Ketamine for Treatment of Chronic Post-traumatic Stress Disorder
A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists
NMDA receptor blockade at rest triggers rapid behavioral antidepressant responses
mTor-dependent synapse formation underlies the rapid antidepressant effect of NMDA antagonists
Signaling Pathways Underlying the Rapid Antidepressant Actions of Ketamine
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
The Ketamine Institute Of Michigan
The Ketamine Institute Of Michigan offers supervised IV Ketamine infusions. After a cleared medical history, you can begin treatment sessions right away. You will be under the care of Dr. Julia Aharonov, a Board Certified Anesthesiologist, and her capable and experienced medical team. Each session should be less than a few hours. IV Ketamine therapy has no addictive properties.
Learn how Ketamine Infusion Therapy is being used to help treat depression and chronic pain.